The analytic range of the CRPH test is designed to detect C-reactive protein concentrations using an initial undiluted (neat) serum sample

The analytic range of the CRPH test is designed to detect C-reactive protein concentrations using an initial undiluted (neat) serum sample. better. No patient has deteriorated. 91.1% of the patients were compliant with medicine during Ramadan, 73.2% after. 89.3% were compliant with diet during Ramadan with no significant change in body weight in the follow-up period. No cardiac or noncardiac morbidity or mortality was reported. High- density lipoprotein-cholesterol (HDL-C) decreased significantly during compared to before fasting (P= 0.012). Low-density lipoprotein-cholesterol (LDL-C) significantly increased during compared to before fasting (P= 0.022). No statistically significant changes were observed in total cholesterol (TC), triglycerides (TG), serum leptin, or hs-CRP. Significant correlation was observed between TC and hs-CRP during fasting (P= 0.036), but not with TG, LDL-C, or HDL-C (P> 0.05). Neither of these correlated with serum leptin (P> 0.05), but significant correlation was observed between hs-CRP and serum leptin (P< 0.05). == Conclusion == Ramadan fasting in stable cardiac patients has no effect on their clinical status, serum leptin, or hs-CRP, but results in RX-3117 decrease in HDL-C, increase in LDL-C, with significant correlation between TC and hs-CRP during Ramadan, but not with TG, LDL-C, or HDL-C, and with significant correlation between hs-CRP and serum leptin before, during, and after fasting. RX-3117 Keywords:serum leptin, hs-C-reactive protein, lipid profile, cardiac disease, Ramadan fasting == Introduction == The Islamic fast during the month of Ramadan, during which a whole month is dedicated to fasting is particular to Islam, and is strictly observed by millions of Muslims worldwide. Since more than a billion people worldwide follow Islam, it is assumed that hundreds of millions of people observe the Ramadan fast each year.1,2 From a physiological standpoint, Islamic fasting provides a unique fasting model. It is distinct from regular voluntary or experimental fasting by the fact that the observant of the fast does not drink during fasting which may reach more than 12 hours. Therefore, one may assume that physiological changes occurring during Islamic fasting would be different from those noted during an experimental fast.3,4Studies on the effect of Ramadan fasting on blood lipids have produced variable results.59Among patients with known stable coronary disease, a correlation between serum C-reactive protein (CRP) and acute coronary events has been demonstrated in some studies.1012In addition, high-sensitivity CRP (hs-CRP) has been shown in some studies to be affected by fasting, weight loss, and with postchallenge glycemia than with fasting glucose levels in nondiabetic subjects.1316 More recently, leptin was found to have multiple roles in the cardiovascular system as a vasoactive substance, in coronary artery vasoreactivity, regulation of myocardial blood flow,17may also have a prothrombotic effect,18and may increase with acute myocardial infarction (AMI).19Serum leptin was independently associated with serum CRP, suggesting that body fat may be the most significant predictor of CRP.20 The most frequently asked question by cardiac patients to their cardiologist is whether Ramadan fasting Rabbit Polyclonal to EPN1 has any adverse effect on their cardiac status. The answer has not yet been clarified. We have previously reported alteration in the time of onset of cardiac events during Ramadan fasting when compared with the rest of the year, where there was a peak of cardiac events during the breaking of fast period.21On the other hand, the prevalence of RX-3117 hospitalization for acute coronary syndrome22,23and heart failure3were not different from the remaining months of the year. The current study complements our previous reports in studying the impact of Ramadan fasting on serum leptin, CRP, and lipid profile among ambulatory patients with stable coronary artery disease. Our aim was to study the effect of strict and prolonged Ramadan fasting on lipid profile, serum leptin, and hs-CRP in stable cardiac patients and check whether.